Quetiapine treatment in Alzheimer’s disease

July 11, 2008

Quetiapine is in the class of drugs known as atypical antipsychotic and is used in treating schizophrenia and mania associated with bipolar disorder.

In a study, 333 patients with Alzheimer’s disease, vascular dementia, or mixed dementia and severe clinical symptoms of agitation received quetiapine or placebo. A total of 219 patients completed the 10-week study, which found that quetiapine reduced agitation in elderly patients with Alzheimer’s disease without leading to a decline in mental function. Fifty-seven percent of patients were noted as much improved or very much improved, compared to 32% in the placebo group. Quetiapine was generally well tolerated.

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