Acetazolamide and Meniere’s disease

July 11, 2008

Acetazolamide is an anticonvulsant drug. This drug may be used in the treatment of glaucoma, seizure disorders, and motion sickness. Acetazolamide has been studied in cats, and had been noted to decrease lymph pressures of the inner ear. In one analysis in The American Journal of Otology, people with Meniere’s disease were given acetazolamide or chlorthalidone and the short-term and long-term effects on the rate of hearing loss were evaluated. Treatment with acetazolamide or chlorthalidone was useful in the testing of hearing function and in managing of vertigo attacks. However, these treatments were not useful in the long-term prevention of hearing loss that occurs with Meniere’s disease. In an earlier study, the immediate effects of acetazolamide were evaluated in 30 patients with Meniere’s disease, where it caused fluid shifts in the inner ear.

In another study from the University of Budapest, 60 patients suffering from Meniere’s disease for more than eight years were treated with acetazolamide in varying doses. This study evaluated the drug’s effects on hearing function and symptoms of tinnitus. Researchers observed successful response to therapy in newly diagnosed patients and those younger than age 50.

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